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Unexpected discovery of a series of "weak" gentlemen
The groundbreaking research of Brigham and Women's Hospital (USA) could pave the way for a completely new treatment for men with weakly armed sperm.
Deeply analyzing the DNA of a number of men struggling to treat infertility, the Brigham and Women's Hospital team scientists discovered they all possessed a strange genetic mutation. This mutation made the men's sperm army smaller and weaker than the average person, despite his good health. It appears common in perennial infertile men, many times treatment fails.
An abnormal genetic mix in chromosomes 20 and 22 made the mutation: it made a gene called SYCP2 up to 20 times more active. SYCP2 again plays an important role in keeping sperm factory functioning properly. Excessive SYCP2 can disrupt and damage the entire sperm production in a gentleman's body.
Mothers of mutants carrying the gene SYCP2 if lucky to be pregnant are also at high risk of miscarriage, so it can be considered as one of the causes of recurrent infertility.
Dr Cynthia Morton, a member of the research team, said the findings could promote more accurate screening methods for men who have reproductive problems. It also paves the way for more targeted interventions - targeting abnormal genes instead of "outside" measures. Dr. Morton said they are moving to larger clinical trials and said they are optimistic with this finding, because science now has the tools good enough to create a treatment in fingertips.